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Reis AS, Paltian JJ, Domingues WB, Novo DL, Bolea-Fernandez E, Van Acker T, Campos VF, Luchese C, Vanhaecke F, Mesko MF, Wilhelm EA (2025) Platinum deposition in the central nervous system: a novel insight into oxaliplatin-induced peripheral neuropathy in young and old mice
At the 12mg dose, 88.8% of participants completed the full 48-week study
robust human dose-finding data remain limited
Patients with progressive kidney failure and usually with less than 10 to 15 percent function usually need dialysis to clear toxins from the body
The "standard" protocol involves ingestion of either placebo (PL) or L-carnitine (LC) in the form of 2 g 60 min before testing
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