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Starting from one of the first studies on this topic, it has been demonstrated that missense mutations on codon 132 in IDH1 gene are present in different tumor types diverse than glioblastoma multiforme or gliomas, including prostate carcinomas [43], opening the way to the investigation of the role of 2-HG also in this tumor type

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Front Neurosci 9:111 Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue

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It plays a critical role in detoxification, immune support, and cellular repair