Higher mean age and baseline SBP, greater use of anti-hypertensive medications, longer T2D duration, and reduction in insulin daily dose might have contributed to explain the difference observed in the impact of weight loss on SBP reduction in these trials, although direct GLP-1R- and GIP-R-mediated effects could also be considered [77]
Mechanism of action: Tirzepatide mimics both GLP-1 and GIP , another gut hormone that can impact blood sugar and appetite
For many people, they improve as the body adapts, but that does not mean they should be ignored if they interfere with eating, drinking, or daily life
Protein drinks are a particularly key area: GLP-1 drugs can cause rapid weight loss, including the loss of muscle tissue (studies show that nearly 40% of weight loss on GLP-1s can be lean mass without proper nutritional support)
Key considerations for patients contemplating a switch from Liraglutide to Semaglutide GLP-1 at our practice include: 8, you must discontinue Liraglutide