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LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept PMID: 35114046 Cell Metab

En promedio, las personas voluntarias del ensayo clnico de retatrutida que recibieron el frmaco del estudio en lugar de un placebo perdieron 70,3 libras (unos 31,9 kg) a lo largo de aproximadamente un ao y medio

The median [mean] overall ABR was 2.0 [3.61] for the 66 patients in the treated population and the median [mean] ABRs for spontaneous and joint bleeding episodes were both 0 [1.18 and 1.12, respectively]

The U.K.s updated guidance is consistent with existing medical guidelines, he said

These factors can reduce effectiveness without representing tolerance