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Oral Medications: Delayed Absorption : GLP-1 receptor agonists slow gastric emptying, which can delay the absorption of oral medications

Nat Rev Dis Primers (2017) 3:17013

While joint pain relief is not an FDA-approved indication for GLP-1 medications, emerging clinical observations and patient reports have prompted investigation into potential musculoskeletal benefits

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Study procedure (Koide et al., 2025) GLP-1RA therapy significantly reduced blood glucose levels, body weight, and body fat percentage Results showed that after 12 months of treatment, GLP-1RA therapy significantly reduced participants blood glucose levels (as measured by glycated hemoglobin), body weight, and body fat percentage