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doi: 10.1053/j.gastro.2017.04.022 8 SongYLiuXChengWLiHZhangD

Augmentation of NKT and NK cell-mediated cytotoxicity by peptidoglycan monomer linked with zinc

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Additional observed toxic mechanisms included loss of MMP, upregulation of the proapoptotic protein Bcl-2-associated X protein (BAX), and downregulation of antiapoptotic markers such as B-cell lymphoma 2 (Bcl-2), poly ADP ribose polymerase (PARP), and caspase-3 [134]