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33,34 A phase 2 clinical study (NCT04313634) using senolytics (D + Q) to treat bone loss in postmenopausal women showed that patients with higher senescent cell burden had a more significant response to D + Q, manifested as a 34% increase in bone formation and an 11% decrease in bone resorption

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For instance, estrogen may interfere with the cross-linking process, leading to a reduction in the mechanical integrity of collagen fibrils

Castells M, Marn S, Sanchis V, Ramos AJ