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Finally, transcriptomic analyses were performed on key metabolic brain regions including the dorsal vagal complex (DVC), LPBN, and mediobasal hypothalamus (MBH), after 21 days of treatment

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The functions of amylin are complementary to insulin and to GLP-1 : Slows gastric emptying , similarly to GLP-1, but more strongly Suppresses glucagon , helps control postprandial glycemia Induces satiety , via the area postrema in the brainstem Regulates weight balance , long-term effect In type 2 diabetes amylin secretion deteriorates in parallel with insulin secretion , as the disease progresses, the -cells lose the ability to produce both hormones at once