To prove that YBX1 functions by binding to mRNAs, we performed an RIP using the anti-YBX1 antibody and found that YBX1 can indeed bind to its own mRNA and also PRKAA1 /2 mRNAs in Huh7 and H1299 cells (Fig
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Mechanistic work in GIPR and GLP-1R knockout mice shows the body-weight effect is preserved when GLP-1R is knocked out but blunted when GIPR is knocked out, indicating GIPR engagement contributes meaningfully to the anorectic phenotype
Deficiency in this vital vitamin can lead to symptoms such as fatigue, weakness, memory issues, mood changes, and even anemia
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