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Reflecting on the intense, around-the-clock effort involved, Alexander noted that the only thing that surprised him was how astonished everyone else seemed to be

Lumo+ uses titanium electrodes in a multipolar configuration with a two-tier dermal heating system that defaults to 42 degrees Celsius and triggers a higher tier for less than 20 seconds when surface temperature reads below the dermal target

The lower dose (100 mg vs 500 mg in standard reduced products) reflects the theoretically higher bioavailability of the acetylated form

Competing Interests The authors report no competing interests

Reviewer information Nature Reviews Disease Primers thanks P