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Who Should Avoid Abrupt Cessation and Why Provider Input Matters Patients with a history of rapid weight regain, binge-eating patterns, or metabolic syndrome face higher rebound risk and should never stop semaglutide without medical oversight

In addition to insulin, pancreatic islets release glucagon, somatostatin, and other pancreatic polypeptides hormones, which collaborate to maintain ideal glucose levels in the bloodstream and control energy metabolism

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Key strategies for combating Wegovy fatigue include maintaining adequate nutrition despite reduced appetite, optimising your sleep environment and schedule, staying properly hydrated, and incorporating gentle physical activity into your routine

So if a patient has severe reflux, Barretts esophagus, or certain other upper GI issues, I may recommend gastric bypass instead