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Saxagliptin given in combination with metformin as initial therapy improves glycaemic control in patients with type 2 diabetes compared with either monotherapy: A randomized controlled trial

2,3 In a Phase I multiple-dose clinical trial conducted in healthy adults, pharmacokinetics were dose-proportional, accompanied by reductions in both fasting and oral glucose tolerance glucose levels

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While GLP-1 receptor agonists (GLP-1-RA) directly target GLP-1, GLP-1-independent effects are also possible with the use of DPP4 inhibitors (DPP4i)

Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects