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TGR IC 50 s for these low MW fragments varied from 0.76 mM to 4.4 mM

Skin and anti-aging focus: Moderate doses (10 to 15 units daily) over longer cycles (12 weeks) allow gradual collagen remodeling without aggressive tissue repair effects

However, due to the unwanted side effects, such as glucose intolerance, insulin resistance, hypertension and edema, exerted by other functional domains of the intact hGH molecule limited its use as pharmacotherapy for obesity In other words, AOD9604 induces fat loss without the side effect of insulin resistance seen in many other peptides that stimulate growth hormone production/release