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Recently, the prescribing information [11] for Wegovy included a warning regarding the risk of thyroid C-cell tumors, although its relevance to humans remains unknown

We show here in a panel of cancer cell lines that GSTO1 knockdown reduced cancer cell viability

Electronic supplementary material Additional file 1: Supplementary Material Model Details for A Mathematical Model of Glutathione Metabolism

But even with these milder options, moderation is key

Biochemistry 40:1413442, PMID: 11714266 Reynaert NL, van der Vliet A, Guala AS, McGovern T, Hristova M, Pantano C, Heintz NH, Heim J, Ho YS, Matthews DE, Wouters EF, JanssenHeininger YM (2006) Dynamic redox control of NF-kappaB through glutaredoxin-regulated S -glutathionylation of inhibitory kappaB kinase beta