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In a randomized trial of semaglutide 2.4 mg vs placebo for 1 year, 529 participants with HFpEF with a BMI of 30 kg/m2, there was a very large reduction in symptoms, improvement in exercise function in the GLP-1 drug assigned group

Zepbound (tirzepatide) : Targets two hormones for enhanced weight loss outcomes

Far less research has taken up a more intimate question: What is it actually like to take them

Rapid or poorly supervised weight loss may increase the risk of: Muscle loss Nutritional deficiencies Gallstones Fatigue Dehydration Hair thinning Healthy, sustainable weight loss is usually gradual and monitored over time