By using AI to analyze more than 400,000 Reddit posts, researchers at Penns School of Engineering and Applied Science have identified patient-reported symptoms associated with GLP-1s, the popular weight-loss and diabetes drugs semaglutide and tirzepatide, that may not be fully captured in clinical trials or regulatory documents
GLP-1R activation in the hypothalamus and brainstem suppresses appetite via POMC neuron stimulation and NPY/AgRP inhibition, slows gastric emptying, and potentiates glucose-dependent insulin secretion
Weight Loss Was Never Just About Willpower If youve followed me for any amount of time, you already know this: Weight gain is not a willpower problem
This, combined with the side effects of oral Wegovy or Rybelsus, like vomiting or diarrhea, could result in dehydration
Generally, you want to get 14 grams of fiber for every 1,000 calories you eat