In turn, glutathione might increase recycling of vitamin C, enhancing its protective effect on oxidative stress (5)
And GLP-1 peptide drugs like semaglutide (Ozempic and Wegovy) and tirzepatide (Mounjaro and Zepbound) have undergone extensive testing in clinical trials to become FDA-approved drugs for obesity and type 2 diabetes
Further research into anti-oxidative agents for ASD begs the question of whether direct supplementation with glutathione is equally or more efficacious than NAC supplementation due to bypassing the rate-limiting transsulfuration step (cysteine) in glutathione synthesis
Abbreviations 2-ME: 2-mercaptoethanol ACN: Acetonitrile BCPB: 1-benzyl-2-chloropyridinium bromide Captopril: [2 S]-1-[3-mercapto-2-methylpropionyl]-L-proline CMLT: 2-chloro-1-methyllepidinium tetrafluoroborate CMQT: 2-chloro-1-methylquinolinium tetrafluoroborate Cys: Cysteine DTT: Dithiothreitol FDA: United States Food and Drug Administration GSH: Glutathione Hcy: Homocysteine Hcy-thioalctone: Homocysteine-thiolactone HPLC-UV: High performance liquid chromatography with spectrophotometric detection LA: Lipoic acid MESNA: 2-mercaptoethanesulfonic acid MPG: N-(2-mercaptopropionyl)-glycine NAC: N-acetylcysteine N-Hcy-Lys: N-homocysteinyllysine RP-HPLC: Reverse-phase high performance liquid chromatography TCA: Trichloroacetic acid TCEP: tris(2-carboxyethyl)phosphine References Lu, S
Espejo AB, Gao G, Black K, Gayatri S, Veland N, Kim J
