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Nevertheless, before initiating SGLT2 inhibitor therapy one should consider factors in the patient history that may predispose them to the need for amputations, such as a history of prior amputation, peripheral vascular disease, severe neuropathy, and diabetic foot ulcers and weigh the risks and benefits of therapy (package insert)

Moreover, the impacts of the interactions between gender and environment factors on IMF deposition cannot be overlooked, even though one of the aforementioned studies showed no significant effects of this interaction on IMF in Beijing-you chickens [57]