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The Proglucagon Family All three peptidesGLP-1, GLP-2, and GLP-3come from the same genetic source but are processed differently: In the pancreas: Proglucagon is processed to produce glucagon In the intestines: Proglucagon is processed to produce GLP-1, GLP-2, and other peptides In the brain: Similar processing occurs with various effects on appetite and metabolism Now, lets explore each peptide individually to understand their unique characteristics

eLife 4 , e06253 (2015)

Therapeutic Scope and the Translational Mismatch Problem Clinically, GLP-1RAs are established therapies for obesity and type 2 diabetes (T2D), with expanding indications and ongoing investigation across multiple organ systems

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Manage Side Effects : Handle nausea with bland foods, stay hydrated for constipation, and rotate injection sites to avoid irritation