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Almost none have heart attacks or strokes

25.40 Compound nevus: ensheathing of the hair follicle as shown in this field is more often a feature of congenital lesions, but can sometimes be seen in acquired melanocytic nevi

This process releases ketones (specifically acetoacetate), which are excreted through urine and can produce a distinct "fruity," "sweet," or "metallic" smell

Moreover, OS can activate various signaling pathways, including the NF-B pathway, which promotes the expression of pro-inflammatory cytokines such as TNF- and IL-6, further contributing to neuroinflammation and neuronal apoptosis (Kumar et al., 2012