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Preclinical research exploring these exact receptor-binding mechanisms is conducted using reference compounds such as GLP-1S, a synthetic long-acting GLP-1 receptor agonist for laboratory use , which models GLP-1 pathway signaling in controlled in vitro and in vivo research settings

In recent years, the p53-inducible gene GLS2 has been found to regulate glutamine metabolism and ROS levels in cancer cells and promote antioxidant defense by controlling the GSH/GSSG ratio [53]