Br J Haematol 122(6):10011008 Wambebe C, Khamofu H, Momoh JA et al (2001) Double-blind, placebo-controlled, randomised cross-over clinical trial of NIPRISAN in patients with Sickle Cell Disorder
They might be caused as a result of structural and chemical changes in the brain
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Chronic conditions often require eight to twelve weeks or longer for significant improvement