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Cell-specific activation of the nrf2 antioxidant pathway increases mucosal inflammation in acute but not in chronic colitis

Inhibit osteoclast activation and differentiation, reduce bone resorption Block osteoclast differentiation signal RANKL/RANK/OPG pathway: AOD 9604 downregulates the expression of RANKL (a key factor in osteoclast differentiation) and upregulates the expression of OPG (a RANKL antagonist), reducing the RANKL/OPG ratio by 50-60% and blocking the differentiation of osteoclast precursors into mature osteoclasts

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The compound's wound-healing properties also benefit post-inflammatory hyperpigmentation, accelerating the resolution of discoloration following acne breakouts or minor skin injuries

Food and Chemical Toxicology, 62 , 869875