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Renal Lifecycle, A Randomized Controlled Clinical Trial to Assess the Effect of Dapagliflozin on Renal and Cardiovascular Outcomes in Patients With Severe Chronic Kidney Disease (NCT05374291)
The hepatotoxicity of ethanol is primarily from metabolism to acetaldehyde, and by reducing ethanol metabolism from ethanol to acetaldehyde, GLP-1R agonism may be hepatoprotective, independent of a decrease in ethanol consumption 14
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Secondary outcomes included nonfatal MI, nonfatal stroke, HHF and renal composite outcome, defined in most trials as a composite of progression to end-stage renal disease or a sustained decrease of at least 40% in estimated glomerular filtration rate (eGFR)
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