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More importantly, chronic administration of these direct blockers leads to up-regulation of DAT expression [12, 13], which possibly underlie the increased risk for subsequent substance use disorders [14, 15]

Since he seemed initially to benefit from this treatment, it is still possible that he was deficient

Second, there are biological risks

10.1021/acsomega.3c08968 20 DuS.ChenX.RenR.LiL.ZhangB.WangQ.et al (2024)