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This observation is consistent with a previous report demonstrating that long-term HFD consumption impaired liver regeneration in C57BL/6 mice through suppression of NF-B activation 44

Shiwei Duan, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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In GCLM KO mouse liver, constitutive activation of AMPK was observed as measured by levels of phosphorylated AMPK and phosphorylated ACC

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