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[DOI] [PMC free article] [PubMed] [Google Scholar] 155.El Eid L, Reynolds CA, Tomas A, et al

Hormonal shifts, sleep disruption, , higher stress levels and more social dinners make it legitimately more difficult to lose fat than it was in your 20s and 30s

These diverse effects are mediated through multiple molecular mechanisms, including metabolic regulation, direct antitumor activities, immunomodulation, and epigenetic modifications