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10.1089/ars.2017.7462 Antioxid Redox Signal

Another crucial point is that, when an individuals antioxidant defense system is weak or saturated, inhaling additional ROS or other reactive metabolites produced by the biotransformation of chemicals in tobacco smoke can increase the amount of oxidative stress caused by the gas-phase and tar-phase derived ROS (60)

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Early studies by Maquart et al