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No benefit was observed from tivantinib treatment, with a median OS of 8.4 months in the tivantinib group compared to 9.1 months in the placebo group (HR 0.97

Alpha-lipoic acid has also reduced inflammatory markers in multiple studies in heart disease patients

Smoking cigarettes involves a substantial amount of free radicals that may degrade exogenous and endogenous antioxidants, as well as dysregulate monocytes and vascular smooth muscle cells [70] Endothelial nitric oxide synthase (eNOS)- derived nitric oxide plays a crucial role in regulating platelet accumulation, vasodilation, and maintaining stability between smooth muscle cell growth and proliferation

GTPases can be divided into two main classes: (i) small monomeric GTPases and (ii) trimeric, receptor-coupled GTPases

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