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Template picking referenced from the cryo-EM map of the compound 2GLP-1RG s complex (EMDB code: EMD-30867) yielded 6,146,299 particle projections, which were subjected to two rounds of 2D classification to discard false positive particles or particles categorized in poorly defined classes, producing 1,497,042 particle projections

By binding to and activating the GLP-1 receptor, it stimulates insulin secretion and lowers glucagon secretion when blood glucose levels are high

The individual mechanisms are well-documented

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