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Overall, these limitations might encourage the search of different approaches, which might combine a more favorable compliance and safety, with acceptable efficacy and with more affordable treatment regimens, and might be therefore particularly suited in a minority of patients experiencing one or more hindrances to PDE5i treatment

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Mechanism in Dermal Tissue A 2025 study published in ScienceDirect examined KPV's effect on particulate matter-induced skin inflammation

This effect was associated with the upregulation of P53 and P21 and the downregulation of CyclinD1 and CyclinB1 [159]

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