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Stimulation of whole blood cells from SZ patients with selective TLR agonists results in enhanced release of pro-inflammatory cytokines (including IL-1, IL-6, IL-8, and TNF-) (150), further supporting the role of TLRs in regulating neuroinflammation in schizophrenia

All controlled studies referenced below were conducted in cell culture (3T3-L1 adipocytes, primary muscle stem cells) or rodent models (diet-induced obese mice, aged C57BL/6J mice)

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The intensification phases may reinvigorate improvement that had plateaued during maintenance

Evidence suggests that epigenetic mechanisms, including DNA methylation, histone modification, and microRNAs, impact the endotheliums ability to respond to blood flow (78)