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This regulation occurs via both SMAD-dependent and non-canonical (PI3K/mTORC2/PDGFR) signaling pathways, and is reinforced by Sirtuin-7 downregulation, which reduces Forkhead box protein O4 (FOXO4)-mediated suppression of GLS1 expression [100]

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Increased sensitivity in the area

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Additionally, both semaglutide and tirzepatide showed promise in improving metabolic dysfunction-associated steatotic liver disease (MASLD), mitigating systemic inflammation, and contributing to improvements in liver-related outcomes, including steatosis resolution and fibrosis-related endpoints, in clinical trials