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SP might inactivate KEAP1, which allowed NRF2 to escape ubiquitination, accumulate within the cell, and translocate to the nucleus 28

A diet high in processed foods and added sugars can disrupt the delicate balance of the gut microbiome, leading to inflammation and oxidative stress

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Another piece of evidence that intestinal oxygen dynamics plays a key role in ferroptosis-mediated microbe-host interactions is that the oxygen gradient established in the gut under physiological conditions is crucial for maintaining microbial ecological balance