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(2018) Prostaglandin E1 plus methylcobalamin combination therapy versus prostaglandin E1 monotherapy for patients with diabetic peripheral neuropathy: A meta-analysis of randomized controlled trials

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Because DSIP primarily promotes slow-wave sleep, daytime drowsiness or grogginess can occur if the peptide disrupts normal sleep-wake patterns

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Potential for pH and Osmolarity Mismatches: While normal saline is isotonic to blood, it isn't necessarily optimized for the stability of a specific peptide structure