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Any forward-looking statements included in this communication speak only as of the date of the communication

109 RiisS.MurrayJ

The activity levels of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and lactate dehydrogenase (LDH), the major enzymes of the glycolytic pathway, are increased in RA synovial cells (14)

Aging Cell 17 , e12768 (2018)

These findings suggest a substantial degree of central sensitization in cirrhosis, highlighting nociplastic pain as a crucial component of chronic pain in these patients (68, 81)