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Less common but important adverse effects include pancreatitis (frequency not known), diabetic retinopathy complications (particularly in patients with pre-existing retinopathy), acute kidney injury (especially in patients who become dehydrated from gastrointestinal symptoms), and gallbladder disease including cholelithiasis and cholecystitis

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[3] Heffernan M, et al

Losing weight doesnt automatically resolve the psychological effects of years of stigma

The rate of denaturation follows an Arrhenius relationship