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[13] These findings are further reinforced by pharmacovigilance data from the FDA Adverse Event Reporting System (FAERS) database (n=48,214 reports), where GLP-1RA-related gastrointestinal adverse events, including nausea (9651 vs 38,030) and vomiting (4383 vs 17,062), were lower with combination therapy compared to GLP-1RA monotherapy, suggesting improved tolerability when metformin is added

In particular, it has been proposed that CSF biopsy may be used to adapt radiotherapy should LMD not respond to other treatments [95]

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Pratley R, Amod A, Hoff ST, et al