Recent dermatological reviews into the pathogenesis of chemical leukoderma highlight Rhododendrol as a primary example of how cosmetic ingredients can inadvertently damage melanocytes
Adam TC, Jocken J, Westerterp-Plantenga MS
The disorder is the result of defects in the mitochondrial matrix enzyme, glutaryl-CoA dehydrogenase (GCDH)
10.1038/s41573-021-00233-1 72 FowlerA
Furthermore, KEGG pathway enrichment analysis demonstrated significant enrichment of purine metabolism, valine, leucine, and isoleucine biosynthesis, arginine biosynthesis, the pentose phosphate pathway (PPP), and histidine metabolism in LPS-induced pneumonia, while papain-induced pneumonia primarily enriched the one-carbon pool by folate, alanine aspartate, and glutamate metabolism, glycine, serine, and threonine metabolism, cysteine and methionine metabolism, and the PPP (Figures 2C, E)