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Notably, there was no evidence that time-varying weight loss mediated the effect of semaglutide on MACE

1, 2, S1-S3 and Table S1 )

All animal experiments were approved by the Animal Ethics Committee of Shandong Provincial Institute of Dermatology and Venereology

An extension analysis of the original STEP-1 trial (n = 327) aimed to observe weight gain and cardiometabolic effects after withdrawal of both SC semaglutide and lifestyle interventions following 68 weeks of therapy

however, the evidence to support this modality in standard practice is lacking, the researchers noted