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[10] [11] Based on data from retatrutide clinical trials (NEJM, 2023) and experience with similar approved agents, patients may experience: Redness, swelling, or itching at the injection site, which typically resolves within a few hours to days Bruising or mild pain immediately following injection Nodules or localised reactions beneath the skin, which may occur with repeated injections at the same site These reactions are generally mild and self-limiting

These systems involve dozens of hormones, neural pathways, and feedback loops that resist sustained weight loss

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They mimic a naturally occurring hormone called glucagon-like peptide-1 (GLP-1), which helps regulate blood sugar levels and appetite