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Further, ~5% of patients are intolerant to metformin 18,20

However, it is always essential to prioritize a foundation of whole foods and proper hydration first

However, one of the most healing agents for the gut is the amino acid glutamine because it is the major fuel source for the enteroendocrine cells

This broad regulatory activity includes upregulation of tissue repair genes, collagen synthesis pathways, antioxidant defense systems, and anti-inflammatory signaling networks, alongside simultaneous downregulation of genes associated with tissue destruction, inflammation, and fibrosis

Important limitation: Neither is FDA-approved in the US, and high-quality Western human clinical trials remain scarce