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Patients and clinicians should nonetheless remain alert to this possibility, particularly given the substantial weight loss retatrutide has produced in phase 2 trial settings (see the New England Journal of Medicine , 2023)

Some may see significant improvements from the very first dose, while others might experience a slower progression

Fragmented care, such as receiving prescriptions from specialists without informing primary care providers, can further disrupt continuity in therapy

If bubbles are in the syringe, hold the syringe straight up and tap the side of the syringe until the bubbles float to the top

View Trial Registration Wilding JPH, Batterham RL, Calanna S, et al