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The brand cites approximately 1.5% annual collagen depletion starting in the 30s, per brand materials

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In my physical therapy clinic, when a patient comes in after losing 10 to 20 pounds through a healthy lymphedema diet and exercise, their measurements are often noticeably smaller, and their compression garments feel looser

But, when a product is in shortage, licensed pharmacies and FDA-registered compounding facilities are permitted to manufacture versions of the FDA-approved product that are essentially a copy of the FDA-approved product until the shortage is resolved