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This does not invalidate the findings but adds a potential source of bias Single-blind only: While the investigator assessing photos was blinded, patients knew whether they received the active serum or saline, which could influence self-reported satisfaction scores No long-term follow-up: The study ended at 6 months

These evaluations were synthesized into a compliance indicator, offering a measurable framework to assess how effectively ISOS values are translated into enforceable rules

Doing so can cause adverse effects on the body, such as allergic reactions, overdose, or unnecessary supplementation

Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) are more detailed scans

Lyophilized powder receives sterile water or bacteriostatic water through controlled syringe transfer into a sealed vial