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Two pathways are especially important in IGF-1 receptor research: PI3K/Akt/mTOR pathway MAPK/ERK pathway The PI3K/Akt/mTOR pathway is often discussed in relation to protein synthesis marker research, survival signalling, nutrient response markers and cellular growth models

10.1073/pnas.1821332116 44 FiebichB

Unlike most senolytics, MOTS-c regulates OXPHOS and stress-related signals such as AMPK or mTORC1 (Figs