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Slowing of Linear Growth Discuss with the patient and caregiver that long-term QSYMIA treatment may attenuate growth as reflected by slower height increase in pediatric patients [see Warnings and Precautions (5.6)]

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These binuclear copper ions are connected to six histidine residues (His 61 , His 85 , His 94 , His 259 , His 263 , and His 296 residues), which further interact with the adjacent residues, viz

This suggests that targeted therapy aimed at Gln metabolism may represent a novel and potentially effective strategy for cancer patients