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Data Extraction Extracted variables included study design, peptide agent and formulation, dosing regimen and route of administration when reported, musculoskeletal indication, comparator group, outcome measures, efficacy findings, and adverse events

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Excipient studies on lyophilized rhGH show that sugar and polyol stabilizers (mannitol, sucrose, trehalose) protect the protein's secondary structure and limit aggregation in the dry state by satisfying water-binding sites and stabilizing the amorphous matrix around the protein (Costantino et al., 1998)