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Zou CY, Liu XK, Sang YQ, Wang B, Liang J

Owing to the rapid degradation of GLP-1 by dipeptidyl peptidase type 4 (DPP-4), it is structurally modified into more stable GLP-1R agonists, such as liraglutide, exenatide, and dulaglutide, which share 97%, 53%, and 90% sequence homology, respectively 12

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Regulation of AP-1 The Activator Protein-1 (AP-1) is a dimeric transcription factor

The simulated results of molecular docking indicated that GHK-Cu can directly bind to SIRT1 to form a protein complex, and the interacting residues in the complex are composed of GLU-230 and ASN-226 (Figure 5E)