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doi: 10.3389/fnut.2025.1642363 Received 06 June 2025 Accepted 17 August 2025 Published 09 September 2025 Volume 12 - 2025 Edited by Kenji Nagao, Ajinomoto (Japan), Japan Reviewed by Ana Beatriz Janurio, Federal University of Pernambuco, Brazil Hiba Hamdar, Plovdiv Medical University, Bulgaria Updates Copyright 2025 Chen, Li, Wang, Liu and Qiu
1 Introduction Berberine (C 20 H 18 NO 4 , IUPAC name: 16,17-dimethoxy-5,7-dioxa-13-azoniapentacyclo [11.8.0.0 2,10 .0 4,8 .0 15,20 ] henicosa-1(13),2,4(8),9,14,16,18,20-octaene, PubChem CID: 2353), an isoquinoline quaternary alkaloid, isolated from different medicinal plants with a molar weight of 336.36 g/mol, including Hydrastis canadensis , Xanthorhiza simplicissima , Berberis aristata , Coptis chinensis , Coptis japonica , etc
